神经科学
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澳门葡京赌博游戏的承诺
神经科学 is a highly collaborative organisation built for agility, 神经退行性疾病的创新和治疗, 慢性疼痛和神经精神适应症. We are working together with our partners to follow the science and discover life-changing medicines to improve patient care in 神经科学.
Our unique approach builds on strong collaborations with leading innovators across industry and academia, facilitating rapid progression of projects from target identification to proof-of-concept studies. Our aim is to address the unmet needs in neurology and chronic pain by advancing innovative molecules through preclinical and clinical development and working with partners to develop breakthrough medicines.
澳门葡京赌博游戏利用数据科学的进步, artificial intelligence and multi-omics to address the particular challenges associated with treating the central nervous system. Through our novel targets and treatment modalities we are working to deliver a portfolio of first and best-in-class medicines for patients.
未满足的医疗需求和疾病流行
5500万年
超过30%
超过2500万
超过8万
澳门葡京赌博游戏的疾病区域
神经退化
Current treatment options for most neurological diseases are limited, particularly for neurodegenerative diseases such as Alzheimer’s disease, 帕金森病, 额颞叶痴呆, 亨廷顿氏病和肌萎缩性侧索硬化症.
We are following the science of key pathways to maximise our opportunity to deliver life changing medicines. Using CRISPR technology we are investigating the potential to repair the gene causing Huntington’s disease. 除了, with Takeda Pharmaceuticals we are exploring ways 来逆转α-突触核蛋白的积累 导致帕金森病的脑细胞.
慢性疼痛
Our work on analgesia – the treatment of pain – includes chronic pain and migraine. 澳门葡京赌博游戏不仅仅是想改善病人对疼痛的控制, we are seeking new ways to transform the lives of people living with chronic pain.
In particular, we’re aiming to alleviate pain for people 谁 cannot benefit from current therapies. 这包括探索疼痛感知的所有阶段. 例如, we have developed unique ways to target the protease activated receptor 2 (PAR2) protein that has been linked to migraine as well as joint inflammation.5
除了, we are opportunistically researching the 神经科学 of addiction with the goal of halting addiction and preventing relapse, 甚至对抗更强效和上瘾的物质. With support from National Institute of Drug Abuse (NIDA) and NIH we are investigating orexins, molecules that are thought to promote behaviours associated with addiction. Finding ways to block orexins could allow more people to overcome their addiction by developing new patterns of behaviour.6
澳门葡京赌博游戏的人民
神经科学小组是一个小的, agile group that are uniquely positioned to rapidly progress opportunities through an extensive network of highly productive partnerships and collaborations.
澳门葡京赌博游戏的团队包括经验丰富的科学家, 临床医生, healthcare and commercial professionals that work closely together to develop and deliver projects with high impact in the 神经科学 space.
神经科学是一个有许多关键医疗需求的领域. Our team is a highly diverse and talented group that are uniquely equipped to build bridges across organisations and create powerful collaborations with great potential to transform our understanding and provide improved treatment and care for patients.
加入澳门葡京赌博游戏的团队
Become part of a team addressing some of the biggest challenges in 神经科学. 澳门葡京赌博游戏的工作范围很广, ever-changing and provides the opportunity to work with leading experts across many different fields. We’re looking for people 谁 are passionate about using science and innovation to improve the lives of people worldwide.
澳门葡京赌博游戏的管道
引用:
1. World Health Organization dementia fact sheet (accessed Feb 2023) http://www.谁.int /新闻/说明书/细节/痴呆
2. 科恩,年代.花瓶，L. 和W. 慢性疼痛: an update on burden, best practices, and new advances. 《澳门葡京赌博游戏》 397;10289, 2082-2097 (2021) doi: 10.1016/S0140-6736(21)00393-7
3. World Health Organization headache disorders fact sheet (accessed Feb 2023) http://www.谁.int /新闻/说明书/细节/头痛疾患
4. 美国国家卫生统计中心.S. Overdose Deaths In 2021 Increased Half as Much as in 2020 – But Are Still Up 15%. 出版日期:2022年5月11日. 访问日期:2023年2月http://www.疾病预防控制中心.gov /卫生/冲压/ nchs_press_releases / 2022/202205.htm
5. Kopruszinski CM, Thornton P, Arnold J，等. Characterization and preclinical evaluation of a protease activated receptor 2 (PAR2) monoclonal antibody as a preventive therapy for migraine. 头痛. 2020;40(14):1535-1550. DOI: 10.1177/0333102420966581
6. Mehr J.比洛蒂，M. 詹姆斯，M。. 食欲素(下丘脑分泌素)和上瘾. 神经科学发展趋势 44;11 852-855 (2021) doi: 10.1016/j.罐头.2021.09.002
Veeva ID: Z4-52073
编制日期:2023年2月